What is a PSA (prostate-specific antigen) test?
A PSA test is a blood test that measures levels of prostate-specific antigen to screen for prostate health conditions and is often required before starting or continuing testosterone replacement therapy.
A prostate-specific antigen (PSA) test measures a protein produced by the prostate gland through a simple blood draw. The test screens for potential prostate health issues, including benign prostatic hyperplasia, prostatitis, and prostate cancer. PSA levels are reported in nanograms per milliliter (ng/mL), with higher levels suggesting possible abnormalities that warrant further evaluation.
For men considering or undergoing testosterone replacement therapy, PSA testing serves as an important baseline and monitoring tool. Since TRT can affect prostate function, many practitioners order a PSA test before starting treatment to establish baseline levels and rule out existing prostate conditions. Depending on initial results and individual risk factors, follow-up testing may occur at regular intervals during therapy to detect any changes that could indicate complications.
A typical PSA screening result under 4.0 ng/mL is generally considered normal, though interpretation varies by age and individual risk profile. Men with elevated PSA levels may need additional diagnostic imaging or specialist consultation before beginning hormone therapy. This precautionary approach helps ensure that TRT candidates are suitable candidates and that ongoing treatment remains safe. Providers offering testosterone replacement therapy typically coordinate PSA screening as part of their comprehensive patient assessment.